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SCFAs, short-chain fatty acids

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GATA binding protein 2 mediates leptin inhibition of PPAR1 expression in hepatic stellate cells and contributes to hepatic stellate cell activation

JACC Cardiovasc Imaging 11:577585

Once fully activated, GLP-1R couples with Gs to activate adenylate cyclase (AC), converting ATP into cyclic adenosine monophosphate (cAMP), thereby increasing the concentration of cAMP

The lateral parabrachial nucleus may be a critical site of action as pharmacological activation of GLP-Rs in the lateral parabrachial nucleus (LPBN) inhibits feeding whereas antagonism of LPBN GLP-1Rs induces hyperphagia (Alhadeff et al., 2014)