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GIP concentration in plasma over 120 min decreases by 75% in Gpr120 / mice upon lard oil gavage compared to wild-type mice (Iwasaki et al., 2015)

For a field that has, for decades, failed to achieve its goals of helping people to lose weight and fat and, more importantly, to keep it off, the GLP-1s have truly changed the game

GLP1 drugs can be life-changing, but theyre not perfect

Zero participants who maintained 30-50g daily fat developed gallbladder issues, while those who went too low-fat had significantly higher gallstone rates

Patients should be advised to contact their GP urgently if hair loss is accompanied by scalp pain, redness, scaling, or loss of follicular openings, as these may indicate scarring alopecia requiring prompt dermatological assessment

For nurses, this raises important ethical considerations: Patient Autonomy vs