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[2] The head-to-head ACHIEVE-3 trial, published in The Lancet in February 2026, compared orforglipron 36 mg to oral semaglutide 14 mg in 1,698 patients with type 2 diabetes over 52 weeks

doi:10.1002/(SICI)1096-9136(199804)15:4 3.0.CO;2-M 10

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In the DPP-4/Diprotin A co-crystal structure (PDB ID 1nu8), the peptide bond between the second and third residues is not cleaved after formation of the tetrahedral intermediate, wherein the sidechain of the catalytic serine (Ser630) is covalently linked to the carbonyl carbon atom Pro2

Sensitivity analyses performed with a random effects model (MHOR 1.04, 95% CI [0.97, 1.11]) and excluding openlabel trials (MHOR 1.03, 95% CI [0.95, 1.10]) provided similar results