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have had their lives changed by GLP-1 medications
10.1016/j.clinthera.2017.10.016 86
[5] This is why GLP-1 receptor agonist drugs cause dramatic reductions in appetite they flood the brain with a much stronger, longer-lasting version of this natural "stop eating" signal
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Semaglutide does not cross the BBB easily, while exendin-4 can [198, 208, 209]
These findings emphasize the need to reconsider the CNS bioavailability of GLP-1RAs and to investigate alternative delivery strategies (e.g., intranasal administration) and molecular designs that improve brain penetrance
