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doi: 10.1177/0300060519865351 Summary Keywords proglucagon, glucagon, GLP-1, GLP-2, oxyntomodulin, diabetes, obesity, multi-agonist Citation Lafferty RA, OHarte FPM, Irwin N, Gault VA and Flatt PR (2021) Proglucagon-Derived Peptides as Therapeutics

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These may include heart rate, blood pressure, glucose measures, liver markers, and adverse events that require medical review

This triple mechanism distinguishes retatrutide from existing licensed treatments such as semaglutide (a GLP-1 receptor agonist) or tirzepatide (a dual GLP-1/GIP agonist)