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Early clinical trial data, most notably from the Phase 2 trial published in the New England Journal of Medicine (Jastreboff et al., 2023), demonstrated that retatrutide produced substantial reductions in body weight up to approximately 24% over 48 weeks at the highest doses studied

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Research confirms that adults using Semaglutide lost about 35 pounds on average, which equals roughly 15% of their starting weight

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GLP-1 and GCG are products of the proglucagon gene, arising from tissue-specific post-translational processing, and share a large degree of sequence homology

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