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On the other hand, with drugs such as Wegovy, some of the underlying metabolic imbalances may persist

Incident or worsening macro-albuminuria fell by 36%, and the annual eGFR decline was numerically slower

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A meta-analysis summarized the results of these randomized trials, showing a significant reduction in MACEs, CV death, stroke, myocardial infarction, death from all causes, heart failure, and kidney disease, emphasizing the important glycometabolic effects and extraglycemic actions that would determine a significant clinical benefit in patients with T2DM [40]