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This aspect of GLP-1RAs can be of great benefit to those with psychiatric conditions who often have a higher risk of heart disease

Weight loss occurred as a side effect in clinical trials, after which doctors increasingly began prescribing the drug to people who are overweight

Key weight loss results at 48 weeks by group: Response rates at 48 weeks (12 mg dose): 100% achieved greater than or equal to 5% weight loss 93% achieved greater than or equal to 10% weight loss 83% achieved greater than or equal to 15% weight loss The cardiometabolic improvements were also significant, with reductions in blood pressure, triglycerides, LDL cholesterol, HbA1c, fasting glucose, and fasting insulin across all dose groups

A dose-dependent dysesthesia signal emerged (8.8% at 9 mg

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It tells the pancreas to make insulin