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10.1016/j.bcp.2021.114817 141 ZhuH.CaiH.WangX.ChenT.ZhenC.ZhangZ.et al (2022)

Among the plethora of novel agents against diabetes, GLP-1RAs are known to exert various biological effects in extra-pancreatic tissues beyond controlling hyperglycemia ( via central mechanisms ( Similarly, SGLT-2is, also referred to as gliflozins, represent another class of anti-hyperglycemic agents currently used in T2D treatment with favorable effects on body weight

The Incretin Concept: From Gut to Glory The story begins with the incretin effectthe observation that glucose taken by mouth triggers a much stronger insulin response by increasing the production of hormones in the pancreas, compared to when it is injected directly into a vein

While some previous studies reported I values or mentioned heterogeneity, they lacked robust sensitivity testing across all outcomes