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Diminished insulin secretion in response to treatment with GLP-1 has been replicated in other studies [[560], [561], [562]]

A previous study showed no acute effects of liraglutide 0.6 mg on 24-h EE, as assessed by indirect calorimetry, after 3 days of treatment in T2DM

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Morton also emphasizes that weight regain is not a personal failure

This structural modification enhances resistance to enzymatic degradation and supports prolonged receptor interaction under experimental conditions

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