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The TYK2 inhibition mechanism differs fundamentally from JAK1/2/3 inhibitors (upadacitinib, tofacitinib, baricitinib) in its allosteric mechanism, which targets the regulatory rather than catalytic domain of TYK2 and produces a more selective kinase inhibition profile with lower off-target activity

Functional hypothalamic amenorrhea and dietary intervention: A systematic review to guide further research in amenorrheic women without overt eating disorder