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Mechanism of Action: Semaglutide, the active ingredient in Rybelsus, is a GLP-1 receptor agonist that mimics the natural hormone GLP-1. It works by increasing insulin secretion, decreasing glucagon secretion, and slowing gastric emptying

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While fasting GLP-1 remained largely unchanged, postprandial concentrations rose markedly at 6 months (total AUC increase in RYGB: ~330%, OAGB: ~259%