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Phase 2 Trial Results (NEJM 2023) The landmark Phase 2 trial enrolled 338 adults with obesity (BMI 30) or overweight with comorbidities (BMI 27) but without diabetes

Withaferin-A s anti-obesity effects are driven by increased energy expenditure via AMPK activation in brown adipose tissue, p38 and ERK1/2 MAPK signaling in brown adipose tissue and subcutaneous white adipose tissue, and subcutaneous white adipose tissue browning

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