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Yes, combining GLP 1 & GIP therapy with other treatments can enhance its effectiveness

10.1016/j.isci.2023.106057 Summary Keywords drug mechanism, metformin, type 2 diabetes, gastrointestinal tract, gut microbiota Citation Cheng M, Ren L, Jia X, Wang J and Cong B (2024) Understanding the action mechanisms of metformin in the gastrointestinal tract

Like the other circumventricular organsthe median eminence, the subfornical organ and the vascular organ of the lamina terminalis, the area postrema contains many cells that express GLP1 receptors (Cork et al., 2015)

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Generally, you need a Body Mass Index (BMI) of 30 or higher, or a BMI of at least 27 if you have related health conditions