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Semaglutide and tirzepatide help control cravings by slowing down digestion and increasing the amount of time your body feels full. This helps control overeating

In Phase 2 cross-trial comparisons, retatrutide produced greater mean weight loss (~24% at 48 weeks) than published tirzepatide data (~2022% at 72 weeks)

Spread protein across several smaller feedings rather than one or two large meals your appetite cannot finish

No meaningful differences were observed between sex-specific estimates, providing no evidence of effect modification by sex ( Supplementary Figures 2 , 3 )

These studies represent emerging efforts to evaluate the potential of GLP-1 RAs as pharmacological interventions for substance use disorders beyond their established role in obesity management