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In that trial, after 72 weeks: People on Tirzepatide lost on average 20.2% of their weight

Even modest weight loss, such as 510% of total body weight, can lead to meaningful changes in hormone balance and metabolic health

Methods We conducted a retrospective cohort analysis using target trial emulation principles on de-identified electronic health records from the TriNetX U.S

The findings highlight that the cardioprotective effects of semaglutide may be independent of adiposity and weight loss, Laurence Sperling, a preventive cardiologist at Emory University not affiliated with the study, told Gizmodo

Decades of research have highlighted the clinical demerits of abnormally high body weight (BW), with BMIs exceeding 30 kg/m 2 and 40 kg/m 2 correlated with decreased life expectancies of three and 10 years, respectively

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