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47 However, it is not advised during pregnancy as it is considered a class C drug, defined as a drug with established risk that cannot be ruled out

GLP-1 mechanism of action when blood sugar levels increase (Source: References[1]) Glucagon-like peptide 1 (GLP-1) is a polypeptide hormone mainly secreted by intestinal L cells

Despite the above preclinical evidence, there is no significant effect on appetite, energy intake or energy expenditure following a GIP acute infusion over a short period

doi: 10.1038/s42255-024-01113-9 12 TurtonMDO'SheaDGunnIBeakSAEdwardsCMMeeranKet al

The Influence of GLP-1 Agonists on Human Mesenchymal Stem Cells: A Systematic Review

they also suppress platelet activity, which may further contribute to cardiovascular protection ( 3.4 Complications and side effects of GLP-1 RAs Common side effects associated with GLP-1 receptor agonists (GLP-1 RAs) include gastrointestinal symptoms such as nausea (2560%), diarrhea, and vomiting (515%) ( While some studies have suggested a possible association between GLP-1 RAs and acute kidney injury (AKI), this has not been confirmed and appears to occur primarily in patients with underlying risk factors such as dehydration or severe gastrointestinal symptoms ( GLP-1 RA therapy should be discontinued under specific clinical conditions to minimize risk