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Author contributions XuW: Writing original draft, Writing review & editing

As a board-certified bariatric and weight loss surgeon, Ive worked with thousands of patients struggling with obesity, metabolic disease, and long-term weight management

Leesburg Medical Weight Loss Specialists Leesburg, Virginia medical weight loss programs at Proactive Wellness Centers feature innovative treatments like GLP-1 therapies, including Semaglutide and Tirzepatide injections

These trials show it helps improve blood glucose levels and supports weight management

However, patient surveys consistently demonstrate strong preference for oral dosing among treatment-naive populations, particularly in Asia Pacific and Latin America where needle anxiety remains culturally prevalent

However, the rates of severe AEs were comparable between all treatment arms