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However, in SURPASS-5, individuals on a background of insulin glargine and tirzepatide reported serious hypoglycemia (19%) more than individuals on a background of insulin glargine and placebo (13%) [14]

Despite promising results in depression and anxiety, GLP-1 RAs have not shown significant benefits in improving cognitive functioning or psychosocial outcomes in schizophrenia or dementia, highlighting the need for cautious optimism and further investigation into their broader neuropsychiatric applications

Rates of Acute Pancreatitis in GLP-1RA Use GLP-1RAs and dual GLP-1/GIPRAs are used to treat type 2 diabetes and, occasionally, for weight management and cardiovascular risk reduction

This study uncovers a new drugdrug interaction between GLP-1RA use and levothyroxine therapy

In some cases, depending on the formulation and provider, there may be oral versions such as tablets or drops

doi: 10.3389/fnagi.2016.00108 77 KosarajuJGaliCCKhatwalRBDubalaAChinniSHolsingerRMet al