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Liver biopsy is considered the gold standard to assess and stage fibrosis but are generally reserved for cases where diagnostic uncertainty exists, given that liver biopsies are invasive and carry the rare but real risk of life-threatening complications

191 The mechanism of GLP-1 RA to improve dopaminergic degeneration and pathological -synuclein aggregation in the PD model may involve inhibiting the PI3K/Akt/mTOR pathway 192 and enhancing AMPK/PGC-1a signaling pathway

Others experience disruption

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

This is an important question without a definitive clinical answer yet

That barrier has now been dismantled