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Tirzepatide vs semaglutide Tirzepatide (Mounjaro/Zepbound) generally provides superior weight loss (up to 22.5%) and blood sugar control compared to semaglutide

GLP1 receptordependent internalisation and transcellular transport of the ligand have been suggested for GLP1 receptor agonists, but not antagonists (Ast et al., 2020

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