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When the body perceives a state of famine (which is what a steep caloric deficit feels like), it begins to downregulate non-essential functions to conserve energy

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Short answer: no, but it depends on what you are optimizing for

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Strategic Overview 14.2.9.4

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This triple-agonist mechanism distinguishes it from every currently approved incretin-based compound

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Reducing Kidney Stone Risk While Taking Wegovy For individuals taking Wegovy, maintaining adequate hydration and adopting preventive strategies can significantly reduce the risk of kidney stone formation

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