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Bupropion causes nausea in roughly 10-15% of users, also most prominently during initiation

(2025, April) Pomegranate

In a direct head-to-head study, people on Zepbound lost an average of 20.2% of their body weight over 72 weeks, while those on Wegovy lost 13.7%

Contraindications and precautions include: Personal or family history of medullary thyroid carcinoma (contraindicated) Multiple endocrine neoplasia syndrome type 2 (MEN 2) (contraindicated) Pregnancy or planning pregnancy (not recommended) Breastfeeding (not recommended) History of severe hypersensitivity to tirzepatide or excipients History of pancreatitis (requires careful assessment) Gallbladder disease or risk factors Severe gastrointestinal disease Diabetic retinopathy (requires monitoring if present) Suicidal thoughts or behaviors (monitor for depression/suicidal ideation) Patients should be advised about reduced oral contraceptive effectiveness and the need for alternative or backup contraception for 4 weeks after initiation and each dose increase

Avoid alcohol, high-fat foods, and caffeine in excess, which amplify nausea when appetite-suppression hormones peak

Disclaimer: Tirzepatide is not FDA-approved for weight loss under its compounded form