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However, it can also cause nausea, diarrhea, constipation, bloating, vomiting, medication interactions, and blood sugar changes

In pooled analyses of the STEP-HFpEF (Semaglutide Treatment Effect in People with obesity and HFpEF) and STEP-HFpEF-DM trials, GLP-1 RA had consistent beneficial effects on HF-related symptoms, exercise function, and inflammatory markers in patients receiving diuretics with obesity-related HFpEF [82]

Two appetite-regulating hormones produced in the digestive tract, ghrelin, an appetite stimulant and pancreatic peptide Y (PYY), a appetite suppressant have been linked to short-term feed behaviors, whereas leptin and to a lesser extent, insulin, are key to chronic weight maintenance over months and years (1)

GLP-1s may work to lower your set point

Many see changes in weight and blood glucose within the first 4-8 weeks, though full benefits often emerge over 3-6 months

PMCID: PMC7197490