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Insulin resistance & prediabetes, National Institute of Diabetes and Digestive and Kidney Diseases (2025) Efficacy and safety of once-weekly semaglutide 2.4 mg versus placebo in people with obesity and prediabetes (STEP 10): a randomised, double-blind, placebo-controlled, multicentre phase 3 trial, The Lancet Diabetes & Endocrinology (2024) With prediabetes, action is the best medicine, American Diabetes Association Prevention or Delay of Diabetes and Associated Comorbidities: Standards of Care in Diabetes2025, Diabetes Care (2025) About the Lifestyle Change Program, CDC (2024)

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For instance, PEG-PLA NPs functionalized with Angiopep-2, a ligand that targets low-density lipoprotein receptor-related protein 1 (LRP1) on BBB endothelial cells, have been used to encapsulate liraglutide

Genes Dev (2005) 19(8):87790.10.1101/gad.1295405 183 HolstJJ

doi: 10.1186/s12933-024-02544-0