new glp-1 drugs in development GLP-1R Agonists for Weight Loss GLP-1 Pipeline Update: February 2025

In addition, a recent in silico molecular docking study regarding the DPP4/CTNNB1/MET signatures showed that stagliptin could be a potential TC drug, however more investigations are surely needed to confirm it ( Gemigliptin Gemigliptin is an orally bioavailable inhibitor of DPP-4, with hypoglycemic and potential renoprotective activities

As concerns liraglutide, Armstrong et al

Acta Obstetricia et Gynecologica Scandinavica

Interestingly, bile acid metabolites have a dual effect on GLP-1 secretion: they can both stimulate and inhibit its production (66)

2 For a diagnosis to be made, it should include two of the three following: (i) hyperandrogenism, whether clinical or biochemical, (ii) ovulatory dysfunction (this also includes cases of regular cycles where anovulation is evaluated by measuring progesterone levels), and (iii) polycystic ovaries on ultrasound, the latter could be replaced by raised levels of anti-Mllerian hormone (AMH) in adults

That's the standard we should be building toward