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As well as physical health risks, the stigma attached to excess body weight and obesity can have adverse psychosocial consequences and lower the quality of life

Fortunately, GLP-1 agonists now offer hope and weight loss success to the thousands of people striving to lose excess fat to improve their health and overall lives

A key mechanism involves their interaction with glial cells, as recent studies show that activated microglia and astrocytes can induce the expression of GLP-1 R, making them direct targets for GLP-1 mimetics [41]

In insulin-treated patients, disordered gastric emptying, even when not associated with gastrointestinal symptoms, can cause a mismatch between the onset of insulin action and the availability of absorbed carbohydrate, leading to suboptimal glycaemic control

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This is exactly why controlled trials are needed and why microdosing should be approached with appropriate medical supervision, not self-experimented with based on internet articles alone