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Without intentional planning, it is easy to eat too little, skip meals, or rely on whatever requires the least effort

Im on Mounjaro

So to answer your question directly, there are some people who probably don't have that thrifty gene, but just the fact of how their lifestyle is they're not physically active, they're eating a lot of highly processed food and so forth they're gaining weight, but that can change quickly depending upon change in their behavior and in their environment

Glucagon-like peptide 1 receptor agonist ameliorates the insulin resistance function of islet cells via the activation of PDX-1/JAK signaling transduction in C57/BL6 mice with high-fat diet-induced diabetes

NHS prescribing of weight loss injections is restricted to specialist weight management services with specific BMI criteria per NICE guidance (TA875, TA664)

They can help find out if there are any other health issues and give advice about your thyroid and what to do about your levothyroxine