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Most people notice initial weight loss within 2-4 weeks of starting GLP-1 therapy, though individual timelines vary based on genetics, dose escalation, and metabolic factors

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In the presence of a -aminobutyric acid type A receptor antagonist, bath application of GLP-1 (100 nM) enhanced PF-PC synaptic transmission, with an increased amplitude of evoked excitatory postsynaptic synaptic currents (EPSCs) and a decreased paired-pulse ratio