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GLP-1 safety trends and emerging side effects While gastrointestinal discomfort is the most common issue, new safety signals continue to emerge

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Last clinically reviewed: May 13, 2026 by the Imbue Health Medical Team 22% Avg

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The decision should be reviewed over time rather than fixed from the first consultation

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Peptides like BPC-157 for gut healing or CJC-1295 with ipamorelin for lean mass preservation are sometimes stacked with dual agonists

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Patients with a history of pancreatitis or significant gastrointestinal issues should be particularly cautious, as incretin-based therapies like Tirzepatide may exacerbate these conditions

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the percentage of lean mass often increases

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