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The most commonly reported adverse effects are gastrointestinal in nature, including bloating, abdominal discomfort, and diarrhea, particularly when consumed in larger quantities

Foundayo, Wegovy, and Zepbound were studied in separate clinical trials with different participants and study designs

This effect has been linked to ER UPR-signaling (118, 119, 141), and ER stress has also been demonstrated to counteract epithelial stemness (142)

While one study did show statistical significance, the FDA said in a Complete Response Letter that it was insufficient on its own [to provide] substantial evidence of effectiveness. The FDA also noted that the NDA submission lacked data on concomitant antipsychotic administration, did not include data that established that the change in negative symptoms was clinically meaningful and that the submitted safety database had an inadequate number of subjects exposed to roluperidone at the proposed dose of 64 mg for at least 12 months

Weight loss is recommended for anyone with BMI over 30, or BMI 2529.9 plus conditions such as type 2 diabetes, hypertension, or heart disease

Kidney Concerns: Dehydration from gastrointestinal side effects can occasionally affect kidney function