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Similarly, exendin-4 injection into the VMH of mice also reduced food intake and body weight, but, interestingly, decreased energy expenditureunlike liraglutide injectiondespite both acting via AMPK inhibition [99]
Intriguingly, disruption of the TM4 dimer interface of GLP-1R differentially impacted the signaling elicited by agonist peptides with a greater abrogation of iCa 2+ mobilization relative to that of either cAMP accumulation or ERK phosphorylation (Harikumar et al., 2012)
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13:18 How GLP-1 Drugs Influence Brain Function and Neuroplasticity Dr
