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For an obese patient, prescribers may have to justify why lifestyle/diet alone is insufficient

Serious side effects are rare

What they need is a better TRT plan

if any are present, do not use the medicine Do not return the medicine to the fridge and use it without seeking advice refrigerating a potentially compromised product does not restore its potency Contact your pharmacist, GP, clinical trial coordinator, or trial site promptly for guidance specific to your product and situation Never administer a medicine that appears visually compromised, even if the storage lapse was brief

Rindi G, Necchi V, Savio A, et al

This is why sealed vials are often shipped with desiccant packs, and why laboratories are advised to keep compounds in low humidity storage environments