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In addition to established efficacy for glycaemic control and weight loss, there has been growing enthusiasm surrounding the cardioprotective effects of GLP-1 agonists, as demonstrated from their superiority to placebo in multiple large studies in preventing major cardiovascular adverse events, namely reduced rates of myocardial infarcts, stroke, and rates of revascularisation procedures (Table 2)

While lifestyle interventions such as diet and exercise can normalize HbA1c, the benefits of GLP-1RA and SGLT2-i extend well beyond glycemic control and justify continuation of therapy

Pacheco-Pantoja EL, Ranganath LR, Gallagher JA, Wilson PJ, Fraser WD

Side effects Common side effects Nausea Diarrhea Vomiting Constipation Abdominal pain Headache Fatigue Injection site reactions Other potential side effects: Indigestion Dizziness Back pain Increased lipase or amylase Altered taste Nasopharyngitis (common cold) Passing gas Bloating Belching Gastroenteritis Decreased appetite Gastroesophageal reflux disease Upset stomach These symptoms often subside as your body adjusts to the medications

Some vendors proactively submit samples to independent labs and publish results

In patients with MASLD and established CVD, GLP-1-based therapies are strongly supported as a cornerstone treatment addressing both hepatic and cardiometabolic disease burden simultaneously