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Similar to K cells, L cells also express the Galinin receptor, GAL 1 , and its activation via Galinin treatment or GAL 1 agonist (M617) treatment prevents the accumulation of cyclic adenosine monophosphate (cAMP) in L cells within primary duodenal cultures in response to the adenylyl cyclase activator, forskolin and inhibits GLP-1 secretion from primary duodenal and ileal cultures (Psichas et al., 2016)

[DOI] [PMC free article] [PubMed] [Google Scholar] 774.Heppner K.M., Marks S., Holland J., Ottaway N., Smiley D., Dimarchi R

American Health Drug Benefits [Internet]

doi:10.1002/jcsm.13677 Sargeant JA, Henson J, King JA, Yates T, Khunti K, Davies MJ

Missing a single dose may result in reduced blood glucose control as therapeutic drug levels decline, potentially causing blood sugar to rise above target ranges

Dual Hormone Action: Tirzepatide activates GLP-1 and GIP receptors