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The GIP pathway does not make fat cells burn fat faster. Instead, early research suggests that tirzepatide helps fat tissue function more normally reducing inflammation, improving adipocyte insulin responsiveness, and increasing adiponectin , a hormone linked to healthier metabolic regulation

They work by mimicking the effects of a hormone called GLP-1, which is released in the gut after eating

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Testosterone can cause virilization (development of male characteristics) in women and is contraindicated during pregnancy due to risk of birth defects

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Since Rybelsus needs to be taken on an empty stomach first thing in the morning, there's no easy way to take a make-up dose, and it's better not to double up