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These parameters are potentially attractive in that there is potential for lowered peak to trough ratio during dosing 40 and therefore potential for a decreased gastrointestinal side effect profile for ALT-801 compared to those typically seen with GLP-1 agonists 41

A balanced diet rich in fiber can also support overall gut health and complement the effects of the medication

Common Side Effects GI effects (most common): Nausea, reduced appetite, constipation or diarrhea are the most frequently reported effects of GLP-1/amylin agents

Because semaglutide slows stomach emptying, large meals may increase nausea, bloating, fullness, reflux, or vomiting

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