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The starting dose of insulin detemir was 10 units/day and the mean dose at the end of the 26-week randomized period was 39 units/day
In contrast, intracerebroventricular injection, even at doses up to 300 ng, failed to influence acute or tonic flinching responses [24]

Greiner TU, Koh A, Peris E, et al

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Typically occurring between ages 45 and 55, perimenopause transition is characterized by fluctuating estrogen levels and declining ovarian function that initiate a cascade of physiological and psychological changes that extend far beyond reproductive health
2009), while DURATION-6 showed substantial decreases in both HbA1c and weight with liraglutide relative to weekly exenatide (Drucker et al