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The SELECT cardiovascular outcomes trial further demonstrated a 20% reduction in major adverse cardiovascular events in overweight and obese adults (Lincoff et al., 2023)
AMPK and the Endocrine Control of Metabolism
A Phase 2 trial (a mid-stage human trial, typically involving a few hundred participants) published in the New England Journal of Medicine in 2023 reported an average weight loss of about 24% at 48 weeks with the highest dose
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