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Individual responses to any GLP-1 therapy - compounded or brand-name - vary significantly based on dosage, duration of use, individual metabolic factors, adherence to treatment, diet, physical activity, and underlying health conditions

Remember that needing to restart or continue GLP-1 therapy is not a failureobesity and type 2 diabetes are chronic conditions that often require long-term medical management alongside lifestyle measures

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Just like any other medicine, a GLP-1 medication is only effective while youre taking it consistently

Both tirzepatide and semaglutide come with boxed warnings from the FDA (the strongest safety warning for prescription drugs) about the risk of developing thyroid C-cell tumors

Metformin, glucose uptake and anaerobic metabolism Metformin increases gut glucose uptake and utilisation It has been known for some time that metformin increases glucose uptake and utilisation in the human intestine, resulting in an increase in lactate production in enterocytes [12, 13]