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Body weight Dose-dependent reductions in body weight were evident vs placebo with tirzepatide 5 mg (6.31 kg [95% CI 4.38, 8.25], I 2 70%), 10 mg (8.43 kg [95% CI 6.77, 10.09], I 2 68%) and 15 mg (9.36 kg [95% CI 6.20, 12.53], I 2 91%) (Fig

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Jakubowicz D, Froy O, Ahrn B et al (2014) Incretin, insulinotropic and glucose-lowering effects of whey protein pre-load in type 2 diabetes: a randomized clinical trial

Particularly noteworthy were the marked differences in serious metabolic and renal complications: lactic acidosis (monotherapy: n = 15,789 vs combination: n = 567), acute kidney injury (7694 vs 675), diarrhea (6922 vs 3890), and metabolic acidosis (4713 vs 203)

Secondly, we used an active comparator, new user design, an approach that minimises biases related to the inclusion of prevalent users

Indeed, GLP-1 RA users in our cohort exhibited more frequent risk factors for pancreatic cancerincluding older age, obesity, type 2 diabetes, and prior gastrointestinal disorderssuggesting a background of increased vulnerability