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The covalent attachment of biotin to the apocarboxylase (i.e., the carboxylase protein without the biotin prosthetic group and is catalytically inactive) is catalyzed by the enzyme, holocarboxylase synthetase (HCS)

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Background and aims: The diagnosis of diabetic polyneuropathy (DPN) mainly focuses on large nerve fibers, however, small nerve fibers (SFs) are also affected

Having quality spring water available throughout the workday makes it easier to refill a glass between meetings, stay refreshed during busy schedules, and keep hydration top of mind without extra effort

Rawish, E

These findings emphasize the need for a personalized approach in clinical decision-making, balancing efficacy goals with tolerability to optimize adherence and long-term outcomes