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To enable genetic associations to be interpreted in units of weight rather than BMI % , we also defined a corresponding weight phenotype, defined as the change in weight from baseline in kilograms

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Gastric Emptying: It slows down the rate at which food leaves the stomach, leading to a prolonged feeling of fullness

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With the potential for sustained efficacy, enhanced patient compliance, and superior safety, these agents could fill an important gap in the treatment landscape

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Both incorporate glucagon receptor agonism alongside GLP-1 activity, but retatrutide takes this further by adding a third target -- GIP receptor agonism -- making it the first triple-hormone receptor agonist in clinical development

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