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To enable genetic associations to be interpreted in units of weight rather than BMI % , we also defined a corresponding weight phenotype, defined as the change in weight from baseline in kilograms

Gastric Emptying: It slows down the rate at which food leaves the stomach, leading to a prolonged feeling of fullness
With the potential for sustained efficacy, enhanced patient compliance, and superior safety, these agents could fill an important gap in the treatment landscape
Both incorporate glucagon receptor agonism alongside GLP-1 activity, but retatrutide takes this further by adding a third target -- GIP receptor agonism -- making it the first triple-hormone receptor agonist in clinical development