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Wider Implications of the Findings The 2023 International Guideline for the Assessment and Management of PCOS provides clinicians and patients with clear advice on best practice, based on the best available evidence, expert multidisciplinary input and consumer preferences

(accessed March 2025)

Hypoglycemia: Low risk due to glucose-dependent mechanism of action

The SLEEVEPASS trial demonstrated that patients who were randomly assigned to either a laparoscopy sleeve gastrectomy or a laparoscopic Roux-en-Y gastric bypass maintained a 43.5% and 50.7% excess weight loss a decade after the procedure

In Phase 1 studies, survodutide was generally well tolerated, with no significant safety or tolerability issues observed in either healthy individuals with overweight or obesity [87, 88]

When caloric intake decreases, the body compensates by slowing metabolism and increasing hunger signals, making sustained weight loss difficult for many individuals