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DM, MAS, EAS, TA, and MH wrote and revised the manuscript
The Foundational Science: How Semaglutide and Tirzepatide Compare To understand the difference, we have to look at the "messengers" (hormones) they mimic

The STEP 5 trial assessed the efficacy and safety of once-weekly subcutaneous semaglutide 2.4 mg versus placebo (both plus behavioral intervention) for long-term treatment of adults with obesity, or overweight with at least one weight-related comorbidity, without diabetes

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placebo (2.4% vs
