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Recent evidence demonstrated that GIPR agonists depend on GIPR signaling in inhibitory AP/NTS GABAergic neurons to decrease body weight and food intake ( 27 , 57 , 58 )

However, some patients report reduced exercise tolerance during initial dose escalation due to the metabolic adjustments occurring

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These approaches, particularly those targeting the permeability of the BBB, are at the forefront of adult stem cell science and hold promise for many future applications