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GLP-1 stands for glucagon-like peptide-1, a hormone that the body naturally produces to help regulate blood sugar levels

These mitochondrial genetic changes may contribute to the age-dependent decrease in MOTS-c levels

While the medication does not directly cause muscle weakness through a neuromuscular mechanism, the combination of fatigue, gastrointestinal symptoms, rapid weight loss, and dietary changes associated with semaglutide therapy creates a clinical context where weakness can reasonably occur as a secondary phenomenon

It does not explain a five-month behavioral shift on its own

doi: 10.2147/DMSO.S51792

Retatrutide is currently an investigational therapy , meaning it is not widely available for general purchase