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Is bloating worse with higher doses
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Proposed, sometimes contradictory, mechanisms for cardiorenal protective effects with SGLT2 inhibitors include enhancement of fuel supply through the production of ketones (the thrifty substrate hypothesis) [118, 119]
Curr Med Res Opin 2012;28:513e23
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(2011) Allosteric modulation of G protein-coupled receptors: a pharmacological perspective
