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Excellent sensitivity of the developed methods is evident by the low LOD and LOQ values calculated for TIR and SEM (Table 3)

The BCPNN analysis further validated these findings, demonstrating that female patients had higher risks of long-term treatment-related adverse reactions, whereas male patients experienced more acute adverse events in the short term

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Weekly losses of 0.5 to 1 pound replace the earlier acceleration

ICH Concept Paper E9 (R1): Addendum to Statistical Principles for Clinical Trials on Choosing Appropriate Estimands and Defining Sensitivity Analyses in Clinical Trials, 2014

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