insulin plus glp 1 GLP-1a: Going beyond Traditional Use Glucagon-Like Peptide-1 Based Therapies: A
Description
GLP-1 receptor agonists (GLP-1RAs), initially approved for diabetes and obesity, are now under investigation for neuroprotective effects in a range of neurological disorders
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In most major obesity trials, GLP-1 therapy was: Escalated to high or maximum tolerated doses Stopped abruptly, not down-titrated Followed by little or no continuation of structured lifestyle support In the STEP-1 extension trial (semaglutide 2.4 mg), participants who discontinued therapy regained approximately two-thirds of their prior weight loss over the following year

The European Medicines Agency has issued a positive recommendation on the same indication

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